• Conformational tuning improves the stability of spirocyclic nitroxides with long paramagnetic relaxation times 

      Sowinski, Mateusz; Gahlawat, Sahil; Lund, Bjarte Aarmo; Warnke, Anna-Luisa; Hopmann, Kathrin Helen; Lovett, Janet E.; Haugland, Marius Myreng (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-05)
      Nitroxides are widely used as probes and polarization transfer agents in spectroscopy and imaging. These applications require high stability towards reducing biological environments, as well as beneficial relaxation properties. While the latter is provided by spirocyclic groups on the nitroxide scaffold, such systems are not in themselves robust under reducing conditions. In this work, we introduce ...
    • Enhanced teaching and learning outcomes from restructuring a basic organic chemistry course 

      Hansen, Jørn Hedløy; Bayer, Annette; Haugland, Marius Myreng (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-10)
      The first course in organic chemistry is tough for many students, and motivation may be an additional serious problem if you are taking the course as a part of your study program but do not intend to become a chemist. The combination of long, speedy traditional lectures, complicated material and the use of an important new language (electron flow arrows) does not contribute to easing the cognitive ...
    • From Differential Stains to Next Generation Physiology: Chemical Probes to Visualize Bacterial Cell Structure and Physiology 

      Hira, Jonathan; Uddin, Md Jalal; Haugland, Marius Myreng; Lentz, Christian Stephan (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-26)
      Chemical probes have been instrumental in microbiology since its birth as a discipline in the 19th century when chemical dyes were used to visualize structural features of bacterial cells for the first time. In this review article we will illustrate the evolving design of chemical probes in modern chemical biology and their diverse applications in bacterial imaging and phenotypic analysis. We will ...
    • Radical Group Transfer of Vinyl and Alkynyl Silanes Driven by Photoredox Catalysis 

      Baussiere, Floriane; Haugland, Marius Myreng (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-08-15)
      Radical group transfer is a powerful tool for the formation of C−C bonds. These processes typically involve radical addition to C−C π bonds, followed by fragmentation of the resulting cyclic intermediate. Despite the advantageous lability of organosilanes in this context, silicon-tethered radical acceptor groups have remained underexplored in radical group transfer reactions. We report a general ...